Module Title
Biotherapeutics
Keywords
genetic disease, gene cloning, biotechnology, gene therapy, pharmacogenomics, immunotherapies |
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Prerequisites for Module
None.
Corequisite Modules
PH4016.
Precluded Modules
None.
Aims of Module
To enable the student to understand molecular biology techniques applicable to gene technology, pharmacogenomics and proteomics and their application to the design, delivery and efficacy of medicinal products.
Learning Outcomes for Module
On completion of this module, students are expected to be able to:
| 1. |
apply knowledge of gene structure and function to the production of biopharmaceuticals.
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| 2. |
discuss how the pharmacogenomic industry has impacted on drug development and the efficacy of drug regimes.
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| 3. |
explain the principles underlying immunotherapies and to describe how they are used in drug targeting and in the treatment of disease.
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| 4. |
appraise and discuss techniques for genetic screening, diagnosis of genetic disease, gene therapy and the regulation of gene expression.
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| 5. |
demonstrate knowledge and understanding of DNA separation techniques and gene cloning and critically evaluate the results obtained.
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Indicative Module Content
Production of recombinant DNAs. Gene cloning. Production of genetically engineered pharmaceuticals.
| Genetic screening and diagnosis. Principles and applications of gene therapy. Mechanism and use of immunotherapies. Relevance of pharmacogenomics and proteomics to pharmacy.
Indicative Student Workload
Contact Hours
| Full Time | Assessment
| 2 | Coursework
| 30 | Lectures
| 18 | Tutorials
| 2 |
Directed Study
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| 50 |
Private Study
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| 48 |
Mode of Delivery
Lectures, coursework (which includes experimental analysis, tutorials and workshops (internal and external/industrial)) and MSCL (which includes PCCAL and directed reading with self-assessment and problem solving).
Assessment Plan
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Learning Outcomes Assessed
| | Component 1 | 1,2,3,4
| | Component 2 | 5
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A written laboratory report based on coursework material.
A closed book examination will be held at the end of the module.
Indicative Bibliography
| 1. | NELSON, D.L. and COX, M.M., Lehninger: Principles of Biochemistry. 3rd ed. New York: Worth Publishers.
| | 2. | TURNER, P.C., MCLENNAN, A.G., BATES, A.D. and WHITE, M.R.H., 2006. Instant Notes: Molecular Biology. 2nd ed. Oxford: Bios Scientific Publishers Limited.
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