Prerequisites for Module
Successful completion of modules PH2015 and PH2022 or their equivalent as determined by the Head of School of Pharmacy.
Corequisite Modules
None.
Precluded Modules
None.
Aims of Module
To provide students with the ability to select and use appropriate methods for the qualitative and quantitative analysis of drugs.
Learning Outcomes for Module
On completion of this module, students are expected to be able to:
| 1. |
appraise the general characteristics of the analytical methods used in drug analysis.
|
| 2. |
explain the principles of the major techniques of instrumental drug analysis.
|
| 3. |
critically evaluate these techniques in the context of quantitative and qualititative drug analysis.
|
| 4. |
apply instrumental techniques in both quantitative and qualitative drug analysis.
|
| 5. |
demonstrate the documentation and interpretation of analytical data.
|
Indicative Module Content
General concepts: purpose of pharmacopeial, pharmaceutical and biopharmaceutical analyses, characterisation, evaluation and comparison of assays and selection of an assay method. Spectroscopic methods: drug assay methods by visible, UV, fluorescence and atomic emission. Structural determination: analysis by UV, IR, nmr and ms. Chromatographic methods: drug quality and quantity by TLC, GLC and HPLC. Underlying importance of chemical structure in all pharmaceutical analysis.
|
Indicative Student Workload
Contact Hours
| Full Time | Assessment
| 2 | Coursework
| 21 | Lectures
| 24 |
Directed Study
| |
| 50 |
Private Study
| |
| 53 |
Mode of Delivery
This module consists of lectures supplemented by coursework (including individual and group problem solving exercises and laboratory small group tutorials), directed reading and self-assessment exercises with answers.
Assessment Plan
|
Learning Outcomes Assessed
| | Component 1 | 1,2,3
| | Component 2 | 4,5
|
Coursework is assessed by one written lab report.
The written examination will be of 2 hours duration and consist of both multiple-choice type questions and longer questions.
Indicative Bibliography
| 1. | CAIRNS, D. 2008. Essentials of Pharmaceutical Chemistry. 3rd Edition. London: Churchill Livingstone.
| | 2. | WILLIAMS, D.H. AND FLEMING, I., 1995. Spectroscopic Methods in Organic Chemistry. London: McGraw-Hill.
| | 3. | HM STATIONERY OFFICE. British Pharmacopoeia. London and web-site.
| | 4. | WATSON, D. 2005. Pharmaceutical Analysis. 2nd Edition. London: Churchill Livingstone.
|
|