Module Title
Biochemistry
Keywords
DNA synthesis, protein synthesis, enzymes, primary and secondary metabolism, regulation, drug metabolism |
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Prerequisites for Module
Successful completion of modules PH1011 and PH1014 or their equivalent.
Corequisite Modules
None.
Precluded Modules
None.
Aims of Module
To provide an introduction to DNA and protein synthesis, enzymes and their control and regulation of metabolic processes.
Learning Outcomes for Module
On completion of this module, students are expected to be able to:
| 1. |
demonstrate an understanding of atomic theory, bonding and basic spectroscopy.
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| 2. |
Discuss the properties and functions of coenzymes and enzymes.
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| 3. |
To generate, manipulate and interpret experimental data relating to biochemistry.
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| 4. |
Describe the regulation of intermediate metabolism in cells.
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| 5. |
Explain the transformation and excretion of drugs and other xenobiotics from body systems.
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Indicative Module Content
Nucleic acids: structure, biosynthesis, regulation of gene expression and protein DNA interactions.
Proteins: the biosynthesis of proteins.
Enzymes: structure, properties, mechanism of catalysis, role, regulatory mechanisms and kinetic analysis.
Intermediate metabolism: overview of glycolysis, tricarboxylic acid cycle [TCA], electron transport chain, oxidative phosphorylation and some inborn errors of metabolism. A detailed review of fatty acid synthesis and oxidation and an understanding of the regulatory mechanisms associated with glycolysis and the TCA cycle.
| Drug metabolism: drug metabolising enzymes, structure, function and factors which affect their activity. The transformation and elimination of drugs from the body.
Indicative Student Workload
Contact Hours
| Full Time | Lectures
| 23 | Coursework
| 27 | Assessment
| 3 |
Directed Study
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| 55 |
Private Study
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| 42 |
Mode of Delivery
Lectures, coursework sessions (which include individual, group practical work with individual reports and tutorials) and managed student centred learning packages (which include the use of CAL material and directed reading).
Assessment Plan
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Learning Outcomes Assessed
| | Component 1 | 1,2,4,5
| | Component 2 | 3
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Component 2: Coursework is assessed by means of an individual practical skills test.
Component 1: One 2 hour written examination consisting of both short answer and essay type questions will be held at the end of the module.
Indicative Bibliography
| 1. | Marks' Basic Medical Biochemistry: A Clinical Approach Eds. Smith, Marks, Lieberman, Second Edition.
| | 2. | Introduction to Drug Metabolism
Eds. G. Gordon Gibson and Paul Skett,Third Edition.
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Additional Notes
Module revised to introduce a more effective means of assessing coursework. Coursework will assess competencies of individual students by mean of a practical skills test.
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