Prerequisites for Module
Successful completion of module PH1015 or equivalent.
Corequisite Modules
None.
Precluded Modules
None.
Aims of Module
To develop an understanding of the origins, properties and actions of drugs.
Learning Outcomes for Module
On completion of this module, students are expected to be able to:
| 1. |
describe the origins, structures and properties of pharmacologically important compounds.
|
| 2. |
demonstrate knowledge of procedures for the extraction and isolation of plant constituents and the assay of natural products.
|
| 3. |
apply the principles of rational drug design to selected classes of drugs.
|
Indicative Module Content
General introduction to Medicinal Chemistry, molecular mode(s) of action of selected drug types, structure activity relationships and rational drug design.
The use of pro-drugs in Medicinal Chemistry.
Amino acids and proteins: origins, structures, properties, extraction and pharmaceutical importance.
Alkaloids: origins, structures, properties, extraction and pharmaceutical importance.
| Steroids: origins, structures, synthesis and pharmaceutical importance.
Indicative Student Workload
Contact Hours
| Full Time | Assessment
| 2 | Coursework
| 23 | Lectures
| 24 |
Directed Study
| |
| 45 |
Private Study
| |
| 56 |
Mode of Delivery
Lectures, coursework sessions (which include individual, group practical work, tutorials and use of PCCAL) and directed study packages (which include problem solving exercises with answers, directed reading with questions, use of internet and online databases for extracting information related to lectures/coursework).
Assessment Plan
|
Learning Outcomes Assessed
| | Component 1 | 1,3
| | Component 2 | 2
|
Component 2 will be assessed by one group report on a selected experiment.
Component 1 will be assessed by one written 1.5 hour examination consisting of MCQ questions and short answer questions to be held at the end of the module.
Indicative Bibliography
| 1. | MARKS, D.M., MARKS, A.D. AND SMITH, C.M. 2004. Basic Medical Biochemistry, a clinical approach.. 2nd Edn Baltimore: Williams and Wilkins.
| | 2. | MCMURRY, J., 2000. Organic Chemistry. 5th ed. New York: Brooks-Cole.
| | 3. | PATRICK, G. L. An Introduction to Medicinal Chemistry 3rd Edn. Oxford University Press.
|
|