Prerequisites for Module
None, in addition to course entry requirements.
Corequisite Modules
None.
Precluded Modules
None.
Aims of Module
To develop an understanding of the physical properties of chemical systems and chemical kinetics relevant to the study of pharmaceutical science.
Learning Outcomes for Module
On completion of this module, students are expected to be able to:
| 1. |
understand the basic physical and chemical properties of pharmaceutical materials.
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| 2. |
explain and apply mathematical expressions in relation to chemical and pharmaceutical systems and demonstrate data analysis and handling.
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| 3. |
demonstrate basic laboratory skills used to generate, manipulate and interpret experimental data.
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Indicative Module Content
Thermodynamics: first, second and third laws; applications of relationships.
Drug solubilities; ideal and non-ideal solutions; colligative properties; colloids, solubility, dissolution.
Physical properties of matter: gases, liquids, crystalline and amorphous solids.
Surface and interfacial tensions; adsorption isotherms.
Surface active agents.
Chemical Equilibrium: equilibrium constants; acids, bases and salts; pH; buffer solutions.
Potentiometric measurements.
Basic uv spectrophotometry, Beer's law.
Rheological flow characteristics of liquids and semi-solids.
| Chemical kinetics of drug decomposition. Order of reactions, rate constants, consecutive and parallel reactions; effect of environmental factors.
Indicative Student Workload
Contact Hours
| Full Time | Assessment
| 4 | Coursework
| 42 | Lectures
| 46 |
Directed Study
| |
| 144 |
Private Study
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| 214 |
Mode of Delivery
Lectures, coursework sessions (these consist of both practical experiments and problem solving tutorials) and Directed Study.
Assessment Plan
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Learning Outcomes Assessed
| | Component 1 | 1,2
| | Component 2 | 3
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Component 2 consists of 2 equally weighted coursework tests. The first consisting of 25 multiple choice questions based on coursework experiments in semester 1. The second consisting of 3 set practical tasks showing competency level based on coursework experiments in semesters 1 and 2.
Component 1 is a written 2 hour examination consisting of multiple choice and short answer questions that will be held at the end of the module.
Indicative Bibliography
| 1. | SINKO, P.J., ed. 2006. Martin's physical pharmacy and pharmaceutical sciences: physical, chemical and biopharmaceutical principles in the pharmaceutical sciences. 6th ed. Philadelphia, Pa.: Lippincott, Williams and Wilkins.
| | 2. | FLORENCE, A.T. AND ATTWOOD, D., 2006. Physicochemical Principles of Pharmacy. 4th ed. London: Pharmaceutical Press.
| | 3. | AULTON, M.E., ed., 2007. Aulton's pharmaceutics: the design and manufacture of medicines. 3rd ed. Edinburgh: Churchill Livingstone.
| | 4. | CAIRNS, D. 2008. Essentials of Pharmaceutical Chemistry. 3rd ed. London: Pharmaceutical Press.
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