Module Database Search

Module Title
Extended Elective Studies (DNA Analysis, Proteomics And Metabolomics)
Reference ASM013 Version 3
Created August 2017 SCQF Level SCQF 11
Approved December 2004 SCQF Points 15
Amended September 2017 ECTS Points 7.5

Aims of Module
To enable students to evaluate the principles, applications and limitations of a number of methods in DNA Analysis, Genomics, Proteomics and Metabolomics.

Learning Outcomes for Module
On completion of this module, students are expected to be able to:
1 Critically appraise the principles and applications of DNA analysis, Proteomics and Metabolomics.
2 Critically evaluate a range of techniques for automated analytical processes.
3 Critically review the following specialist area: DNA Analysis, Proteomics and Metabolomics.

Indicative Module Content
Composition, structure and properties of DNA and proteins. DNA and protein synthesis (gene expression). Basic human genetics. Separation techniques: gel and capillary electrophoresis applied to DNA and proteins. DNA analysis and genomics will include principles and applications of PCR (polymerase chain reaction), DNA sequencing, DNA finger printing, DNA micro-arrays. Analysis of: sequence data, genetic variation, gene expression and gene functions. Mass spectrometry of large biomolecules using MALDI TOF and Electrospray methods. Proteomics including protein purification and separation. 2-D gel electrophoresis, handling of proteins and peptide samples for proteomics, mass spectroscopic and computational techniques for peptide sequencing, Edmann degradation technique and data searching with mass spectra. An introduction to secondary metabolites. Chromatographic methods used to study metabolites. Sample extractions. Automated methods: Technicon auto analyser, flow injection Analysis, Laboratory robotics techniques, advantages and disadvantages.

Module Delivery
This course is delivered mostly by formal lectures with some external specialist speakers.

Indicative Student Workload Full Time Part Time
Contact Hours 25 25
Non-Contact Hours 125 125
Placement/Work-Based Learning Experience [Notional] Hours N/A N/A
TOTAL 150 150
Actual Placement hours for professional, statutory or regulatory body    

If a major/minor model is used and box is ticked, % weightings below are indicative only.
Component 1
Type: Coursework Weighting: 100% Outcomes Assessed: 1, 2, 3
Description: Component 1 will be a critical review of the principles and applications of DNA analysis, proteomics and metabolomics.

Explanatory Text
To pass this module students must achieve a module grade D or better. The grading criteria are:-
Module Grade Minimum Requirements to achieve Module Grade:
A Final mark must be greater than or equal to 70%
B Final mark must be between 60-69%
C Final mark must be between 50-59%
D Final mark must be between 40-49%
E MARGINAL FAIL. Coursework mark must be between 35-39%
F FAIL. Coursework mark is less than 35%
NS Non-submission of work by published deadline or non-attendance for examination

Module Requirements
Prerequisites for Module In addition to course entry requirements, students must be familiar with the basic principles of chromatography, spectroscopy, microscopy and electrochemistry.
Corequisites for module None.
Precluded Modules None.

1 DALE, J.W. AND VON SCHANTZ, M., From Genes to Genomes, Concepts and Applications of DNA Technology. Wiley.
2 LESK, A.M. Introduction to Bioinformatics. Current Edition. Oxford University Press.
3 SKOOG, D.A., HOLLER, F.J. and CROUCH, S.R. Principles of Instrumental Analysis. Current Edition. Belmont, CA: Thomson Higher Education.
4 KOLEV, S., and MCKELVIE, I. Advances in Flow Injection Analysis and Related Techniques. Current Edition. Amsterdam: Elsevier.

Robert Gordon University, Garthdee House, Aberdeen, AB10 7QB, Scotland, UK: a Scottish charity, registration No. SC013781