Module Title
Transfusion Science
Keywords
Antibiotics, Blood Groups, Antibody Screening, Histocompatability, Immunogrenetics, Transfusion Centres, Blood Products |
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Prerequisites for Module
The student should be familiar with the content of modules AS3011, AS3055
Corequisite Modules
Refer to Definitive Course Document.
Precluded Modules
Refer to Definitive Course Document.
Aims of Module
To provide the student with the ability to explain the essential features of transfusion sciences.
Learning Outcomes for Module
On completion of this module, students are expected to be able to:
| 1. |
Explain the nature and clinical importance of the main human blood groups.
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| 2. |
Discuss the significance of histocompatability and immunogenetics in transplantation and blood transfusion.
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| 3. |
Summarise the nature and applications of techniques/procedures used in transfusion science.
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| 4. |
Give an accurate account of the operation of a blood transfusion centre.
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| 5. |
Describe and explain good practice in the preparation of blood-derived products.
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Indicative Module Content
Haemagglutination. Serological techniques, ABO, RhD and other blood groups. Antibody screening, compatibility testing, transfusion reactions. HDN antibody monitoring, anti-D prophylaxis programme. Autoimmune Haemolytic Anaemias. Blood group reagent red cells/antisera, selection of grouping controls. Transfusion Centres. Effective operation, good practice, quality control. Blood products preparation: erythrocytes, platelets, plasma, clotting factors, other biopharmaceutical products related to blood, including recombinant blood products. Histocompatability and immunogenetics. Evolution, function, genetic organisation, role in transplantation and blood transfusion, genetic anthropology and epidemiological studies. Methods for HLA typing: serological and molecular biology techniques. Alloimmune thrombocytopenia: laboratory investigation, causes, therapies. Blood stem cells: allogenic peripheral blood stem cells and bone marrow collection, processing, storage, quality assurance.
| Indicative Student Workload
Contact Hours
| Full Time | Lectures
| 20 | Tutorials/external visits
| 15 | Supervised Assessments
| 0 |
Directed Study
| | Directed Study
| 35 |
Private Study
| | Private Study
| 80 |
Mode of Delivery
This is a lecture-based course, with directed reading of textbooks and journal articles. Tutorials will be used for discussion of case studies of clinical and bioproduction data. The practical nature of transfusion science will be emphasised by visits to a blood transfusion centre and laboratories.
Assessment Plan
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Learning Outcomes Assessed
| | Examination | 1,2,3,4,5
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Indicative Bibliography
| 1. | AABB Technical Manual (11th Edit) (1993).
| | 2. | G Daniels, Human Blood Groups, Blackwell (1995).
| | 3. | J L Bidwell & C Navarrete, Histocompatibility Testing, Imperial College Press (2000).
| | 4. | J R Harris, Blood Separation and Plasma Fractionation Wiley (1991).
| | 5. | W D Judd, Methods in Immunohaematology (2nd Edit) Montgomery Scientific (1994).
| | 6. | V Prowse, Plasma and Recombinant Blood Products in Medical Therapy, Wiley (1992)
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