Prerequisites for Module
The student must be familiar with introductory courses in aliphatic, aromatic and biological chemistry (AS2054 and AS2003) and organic synthesis (AS3003) or their equivalent
Corequisite Modules
Refer to Definitive Course Document.
Precluded Modules
Refer to Definitive Course Document.
Aims of Module
To enable the student to assess the mode of action of drugs and the principles of drug discovery, design, synthesis and development.
Learning Outcomes for Module
On completion of this module, students are expected to be able to:
| 1. |
Explain the mode of action of pharmaceutical drugs and outline the importance of SAR and QSAR in drug design.
|
| 2. |
Discuss new technological approaches to drug design and discovery and their development into clinical drugs.
|
| 3. |
Discuss the receptor theory.
|
Indicative Module Content
Drug action and design: receptor theory, relation between chemical structure and biological activity, detection and measurement of drug effects, site of drug action, analysis of drug-receptor interactions and relation between dose and effect. SAR and QSAR. Mechanism into the mode of action of antiviral and anticancer drugs. Combination therapy. Principles of drug discovery and development. Drug Synthesis: Synthesis of peptide, nucleosides and oligonucleotides. Analogues as therapeutic agents. Solid phase synthesis applied to combinatorial chemistry.
| Indicative Student Workload
Contact Hours
| Full Time | Lectures
| 30 | Tutorials/Case Studies
| 10 |
Directed Study
| | Directed Study
| 40 |
Private Study
| | Private Study
| 70 |
Mode of Delivery
This is a lecture based course supplemented with tutorial sessions and case studies.
Assessment Plan
|
Learning Outcomes Assessed
| | Examination | 1,2,3
|
The examination will consist mainly of extended response questions.
Indicative Bibliography
| 1. | T W G Solomons, Organic Chemistry (6th Edit.), Wiley, (1996).
| | 2. | C Wermuth, The Practice of Medicinal Chemistry, Academic Press, (1996).
| | 3. | L P Graham, An Introduction to Medicinal Chemistry, Oxford University Press, (2001).
|
|