Prerequisites for Module
Molecular Biology & Human Genetics (AS3015) or equivalent.
Corequisite Modules
Refer to Definitive Course Document.
Precluded Modules
Refer to Definitive Course Document.
Aims of Module
To provide students with the concepts and principles underlying DNA analysis for forensic applications and human disease diagnosis.
Learning Outcomes for Module
On completion of this module, students are expected to be able to:
| 1. |
Describe DNA profiling systems and the technical differences underlying each method in current use.
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| 2. |
Explain the procedures for the collection of biological samples for analysis.
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| 3. |
Discuss the role of DNA analysis for diagnosis of human disease.
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Indicative Module Content
Basis of nucleic acid typing systems. DNA polymorphisms used in forensic laboratories. Procedures used for forensic DNA fingerprinting. Sources of DNA samples for analysis. DNA extraction and preparation procedures.
DNA diagnostic tests. Hereditary disorders. Gene mutation. Genetic counselling. RFLP. PCR.
Indicative Student Workload
Contact Hours
| Full Time | Lectures
| 30 | Tutorials/Seminars
| 10 |
Directed Study
| | Directed Study
| 40 |
Private Study
| | Private Study
| 70 |
| Mode of Delivery
The module comprises lectures supplemented with tutorials and guided reading.
Assessment Plan
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Learning Outcomes Assessed
| | Coursework | 3
| | Examination | 1,2
|
Coursework assessment for outcome 3 will be a case study.
Indicative Bibliography
| 1. | Forensic DNA Typing: Biology and Technology Behind STR markers, M Butler, Academic Press (2000).
| | 2. | Forensic DNA Profiling Protocols. Methods in Molecular Biology, Volume 98, PJ Lincoln et al, Humana Press (1998).
| | 3. | Evaluation of Forensic Science DNA Evidence: Update on Evaluating DNA Evidence, National Research Council, Committee on DNA Technology in Forensic Science (1996).
| | 4. | Polymerase Chain Reaction: A Practical Approach, Volume 1, MJ McPherson et al, (1994).
| | 5. | Polymerase Chain Reaction: A Practical Approach, Volume 2, MJ McPherson et al, (1994).
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