Module Title
Clinical Chemistry
Keywords
Inherited Metabolic Disease, Endocrine Disorders, Endocrine Related Metabolic Disorders, Nephrology, Gastroenterology, Hepatology, Diagnosis, Health Monitoring. |
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Prerequisites for Module
The student should be familiar with analytical techniques (AS2001 & AS3201), biochemistry (AS2003 & AS3004) and anatomy and physiology (AS2055 & AS3061).
Corequisite Modules
None.
Precluded Modules
None.
Aims of Module
To provide the student with the ability to apply the principles of clinical science to the diagnosis and treatment of disease.
Learning Outcomes for Module
On completion of this module, students are expected to be able to:
| 1. |
Explain the diagnosis and treatment of selected metabolic disorders.
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| 2. |
Identify the factors which can lead to the development of cardiovascular, gastrointestinal, renal and liver disorders and explain how these can be diagnosed and subsequently treated.
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| 3. |
Apply prior knowledge and understanding of the principles of enzymology to the diagnosis of disease.
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| 4. |
Relate manifestations of disease to disorders of metabolic and endocrine function.
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| 5. |
Explain how pregnancy can be confirmed and how maternal and foetal health can be monitored.
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Indicative Module Content
Clinical enzymology: origin and function of serum enzymes, enzyme replacement therapy, isoenzymes, tumour markers, examples of enzymes used in diagnosis, effect of selected drugs on serum enzyme levels. Inherited and endocrine-related disorders of carbohydrate and lipid metabolism: diagnosis and treatment. Clinical endocrinology: diagnosis of endocrine dysfunction, thyroid and steroid hormones, thyroid function tests. Cardiovascular disease: platelet functions, thromboses and atherosclerosis. Liver disease: liver function tests, jaundice. Gastroenterology: gastric and duodenal function tests, malabsorption syndromes. Clinical chemistry of the kidney and related disorders: role of kidney in homeostasis of nitrogen, renal function tests, creatinine, gout and aminoacidurias. Clinical chemistry of pregnancy and lactation: pregnancy tests, prenatal diagnosis of birth defects, hormonal monitoring of foetal and maternal health, postnatal screening tests.
| Indicative Student Workload
Contact Hours
| Full Time | Lectures
| 20 | Tutorials/Case Studies
| 5 | Supervised Assessments
| 5 |
Directed Study
| | Directed Study
| 60 |
Private Study
| | Private Study
| 60 |
Mode of Delivery
This is a lecture and case study oriented course supplemented with directed reading, seminars and tutorial sessions.
Assessment Plan
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Learning Outcomes Assessed
| | Coursework | 1,2,3,4,5
| | Examination | 1,2,3,4,5
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Indicative Bibliography
| 1. | W. J. Marshall "Clinical Chemistry" (4th Edition), Mosby (2000).
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