Prerequisites for Module
Modules AS1901, AS2901 and AS2902 or equivalents.
Corequisite Modules
None.
Precluded Modules
None.
Aims of Module
To understand and apply principles of pharmacology in the context of disease processes and drug action.
Learning Outcomes for Module
On completion of this module, students are expected to be able to:
| 1. |
Explain the basic principles of drug action.
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| 2. |
Explain the absorption, distribution, metabolism and elimination of drugs.
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| 3. |
Discuss the mode of action of selected groups of drugs.
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| 4. |
Manipulate and interpret experimental data and to select and apply appropriate statistical techniques.
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Indicative Module Content
Routes of drug administration, uptake and transporter systems, bioavaialability, neurotransmitters, endocrine and paracrine messengers, G-protein coupled receptors, nuclear hormone receptors, tyrosine kinase receptors, ligand-gated ion channels.
Pharmacokinetics, Phase I and Phase II metabolism, excretion, pharmacogenetics, single gene regulation, polymorphism, slow and fast metabolisers, N-acetyltransferase, cholinesterase, debrisoquine polymorphism, ageing effects.
| Cholinergic and adrenergic agonists,gastrointestinal drugs, insulin, diuretics, antibacterial, antiviral, anticancer drugs, steroidal and non-steroidal agonists and antagonists.
Indicative Student Workload
Contact Hours
| Full Time | Computer based exercises
| 6 | Laboratory based practicals
| 12 | Lectures
| 18 | Tutorials
| 4 |
Directed Study
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| 40 |
Private Study
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| 70 |
Mode of Delivery
Lectures with associated tutorials, computer-based exercises and laboratory practicals.
Assessment Plan
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Learning Outcomes Assessed
| | Component 1 | 1,2,3
| | Component 2 | 4
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Component 2 is assessed by a formal laboratory report
Component 1 is assessed by a group presentation on a pharmacological case study.
Indicative Bibliography
| 1. | HARVEY, R.A., CHAMPE, P.C., FINKEL, R., CUBEDDU, L. and CLARKE, M.A. Lippincott's Illustrated Reviews: Pharmacology. Current Edition. Wolters Kluwer
| | 2. | GOLAN, D.E., TASHIJAN, A.H. Jr., ARMSTRONG, E.J. and ARMSTRONG, A.W. Fundamental Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy. Current Edition. Wolters Kluwer.
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