Prerequisites for Module
Students should be familiar with the content of module AS2003 or its equivalent
Corequisite Modules
Refer to Definitive Course Document.
Precluded Modules
Refer to Definitive Course Document.
Aims of Module
To enable students to explain metabolic pathways, their regulation, and the biological importance of their products.
Learning Outcomes for Module
On completion of this module, students are expected to be able to:
| 1. |
Describe the nature and sequence of the biochemical reactions in the principal metabolic pathways of carbohydrates, lipids and proteins.
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| 2. |
Discuss the biological significance and fates of the metabolic intermediates and end products of the principal metabolic pathways.
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| 3. |
Discuss the major control sites in metabolic pathways, the mechanisms for their control and give an accurate and reasoned account of the integration of metabolism.
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| 4. |
Explain selected disorders of metabolism in terms of molecular abnormalities and their metabolic consequences.
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Indicative Module Content
Carboydrate metabolism: glycolysis, physiological significance of anaerobic and aerobic metabolism, the citric acid cycle. Pentose phosphate pathway. Gluconeogensis, glycogenolysis, glycogen synthesis. Mechanisms of control of carboydrate metabolism. Lipid metabolism: dietary lipids, catabolism of triacylglycerols and fatty acids. Biosynthesis of fatty acids. Control of fatty acid metabolism. Protein metabolism: protein turnover, hydrolysis of proteins, degradation of amion acids, urea cycle. Integration of metabolism: major control sites and junctions. Enzyme regulation, metabolic regulators, hormone regulators. Metabolic adaptions and alterations.
| Indicative Student Workload
Contact Hours
| Full Time | Lectures
| 36 | Tutorials/Seminars
| 6 | Supervised Assessments
| 2 |
Directed Study
| | Directed Study
| 38 |
Private Study
| | Private Study
| 68 |
Mode of Delivery
This is a lecture based course supplemented with tutorial sessions and guided reading.
Assessment Plan
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Learning Outcomes Assessed
| | Coursework | 4
| | Examination | 1,2,3
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Indicative Bibliography
| 1. | P C Champe & R A Harvey, Lippincott's Illustrated Reviews: Biochemistry (2nd Edition), J B Lippincott Company (1994).
| | 2. | L Stryer, Biochemistry (4th Edition), W H Freeman & Co. (1995)
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