Module Title
Biomedical Analysis
Keywords
Statistics, calibration, standard operating procedures, atomic and molecular spectroscopy, hospital laboratory accreditation schemes, automated analysers, Certificate of Competence Portfolio of Registration. |
|
Prerequisites for Module
Successful completion of Stage 2 or equivalent
Corequisite Modules
None.
Precluded Modules
None.
Aims of Module
To enable the student to develop a deeper understanding of analytical techniques and assess a range of diagnostic techniques used in biomedical analysis.
Learning Outcomes for Module
On completion of this module, students are expected to be able to:
| 1. |
Apply appropriate methods of statistics, calibration and sampling.
|
| 2. |
Explain the theoretical principles and applications of atomic and molecular spectroscopy.
|
| 3. |
Explain the implementation and advantages of quality assurance e.g. NEQAS, quality control and selected accreditation systems for pathology laboratories in the UK.
|
| 4. |
Summarise the principles of automated and manual methods of pathological analysis and discuss the significance of reference ranges and reference materials.
|
| 5. |
Describe the principles and apply the practice of standardisation and calibration as they relate to procedures which comply with standard operating procedures.
|
Indicative Module Content
The importance and practice of sampling and sample pre-treatment. Calibration methods: normal, standard additions, internal and external standards. Statistical methods: design of experiments, analysis of variance (ANOVA), ideal methods, sources of error, sample problems, human variability.
Introduction to analytical spectroscopy; absorption and emission of radiation by atoms and molecules, instrumentation, techniques, applications.
The principles of continuous flow, multichannel, discrete, selective, random access, centrifugal and kinetic end-point analysers.
| Management and safety in the modern hospital laboratory. The role and practice of quality assurance, quality control, pathology laboratory accreditation systems, local and national reference ranges and materials.
Compliance with standard operating procedures.
Indicative Student Workload
Contact Hours
| Full Time | Assessment
| 8 | Laboratory Work
| 6 | Lectures
| 28 | Tutorials
| 4 |
Directed Study
| |
| 40 |
Private Study
| |
| 64 |
Mode of Delivery
This module is delivered mostly by formal lectures with appropriate tutorial support. Statistics and calibration will involve the use of appropriate computer software and Learning Outcome 5 is to be performed in the laboratory.
Assessment Plan
|
Learning Outcomes Assessed
| | Component 1 | 1,2,4
| | Component 2 | 3,5
|
Component 1 is a closed book examination at the end of the Semester.
Component 2 is an assessment of compliance with standard operating procedures using appropriate calibration and standardisation techniques.
Indicative Bibliography
| 1. | BURTIS, C.A., ASHWOOD, E.R., and BRUNS, D.E., 2005. Tietz Textbook of Clinical Chemistry and Molecular Diagnostics. 5th ed. Elsevier Health Sciences
| | 2. | MILLER, J.N., and MILLER, J.C., 2005. Statistics and Chemometrics for Analytical Chemistry. 5th ed. Pearson Education.
| | 3. | SKOOG, D.A., HOLLER, F.J. and NIEMAN, T.A., 2006. Principles of Instrumental Analysis. 6th ed. Thomson Brooks/Cole.
|
Additional Notes
This module covers, at least in part, the following Health Professions Council Standards of Proficiency for Biomedical Scientists (035/SOP/BMS/A5 July 2004): 1a.1, 2b.4, 2c.1, 3a.1.
The Certificate of Competence and Portfolio of Registration refers only to students on the Applied Biomedical Science course.
|
|