Module Title
Molecular Genetics
Keywords
Mendelian Genetics, Transformation, Transduction, Conjugation, Dna Replication, Transcription And Translation, Gene Regulation. |
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Prerequisites for Module
AS1002 & AS1153 or equivalent.
Corequisite Modules
Refer to Definitive Course Document.
Precluded Modules
Refer to Definitive Course Document.
Aims of Module
To provide the student with the ability to discuss the significance and fundamental aspects of Mendelian and molecular genetics.
Learning Outcomes for Module
On completion of this module, students are expected to be able to:
| 1. |
Define the principles of herdity and apply them to problem solving.
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| 2. |
Describe the microbial genetic exchange process and discuss their significance in confirming DNA as the genetic material.
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| 3. |
Explain the processes of gene expression and distinguish between mechanisms in prokaryotes and eukaryotes.
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| 4. |
Discuss the regulatory process controlling gene expression in prokaryotes and eukaryotes.
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Indicative Module Content
Mendelian Genetics: Mendel's Laws, inheritance, genotype, phenotype, dominance, incomplete dominance, co-dominance, polygenic inheritance, sex linkage, gene mutation. Microbial genetic exchange processes; transformation, conjugation and transduction. Molecular Genetics: Central dogma of molecular biology, replication of DNA and role of DNA polymerase in template directed synthesis, transcription and RNA polymerase, sigma factor and promoter recognition, structure and function of ribosome¿s in translation, genetic code, role of amino acyl tRNA, protein synthesis. Gene regulation: operon theory and induction/repression of gene expression, catabolite repression, attenuation, enhancers, zinc fingers, leucine zippers, post-transcriptional/translational modification, gene splicing, catalytic RNA.
| Indicative Student Workload
Contact Hours
| Full Time | Lectures
| 36 | Tutorials/Seminars
| 12 | Supervised Assessments
| 3 |
Directed Study
| | Directed Study
| 44 |
Private Study
| | Private Study
| 55 |
Mode of Delivery
This is a lecture based course supplemented with student centred learning activities supported by tutorial sessions.
Assessment Plan
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Learning Outcomes Assessed
| | Coursework | 1,2,3
| | Examination | 1,2,3,4
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There will be 3 elements of coursework each worth 15%:
(i) Class Test - LO3
(ii) Homework Exercise - LO1
(iii) Homework Exercise - LO2
The examination will consist of an appropriate balance of short response questions and extended response questions.
Indicative Bibliography
| 1. | Griffiths, A.J.F., Wessler, S.R., Lewontin, R.C. and Carroll, S.B., 2007. An Introduction to Genetic Analysis (9th Edition). W H Freeman and Co.
| | 2. | Hartl, D.L. and Jones, E.W., 2005. Essential Genetics (4th Edition). Jones and Bartlett Inc.
| | 3. | Lodish, H., 2007. Molecular Cell Biology (6th Edition). W H Freeman and Co.
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